Multiple mechanisms of action associated with VASCEPA based on clinical and mechanistic studies support the rationale to test its effects in patients with or at risk for COVID-19 disease. J Am Coll Cardiol. (See Amarin stock analysis on TipRanks)“We believe physician and patient education on the benefits of Vascepa remains paramount for widespread adoption, and our concern is that this educational and promotional push could be greatly reduced or eliminated with introduction of a non-branded generic competitor,” Fein wrote in a note to investors.

People with elevated triglycerides have 35% more cardiovascular events compared to people with normal (in range) triglycerides taking statins.15,16,17About REDUCE-ITREDUCE-IT was a global cardiovascular outcomes study designed to evaluate the effect of VASCEPA in adult patients with LDL-C controlled to between 41-100 mg/dL (median baseline 75 mg/dL) by statin therapy and various cardiovascular risk factors including persistent elevated triglycerides between 135-499 mg/dL (median baseline 216 mg/dL) and either established cardiovascular disease (secondary prevention cohort) or diabetes mellitus and at least one other cardiovascular risk factor (primary prevention cohort).REDUCE-IT, conducted over seven years and completed in 2018, followed 8,179 patients at over 400 clinical sites in 11 countries with the largest number of sites located within the United States.

This breaks down into 4 recent Buy ratings versus 4 Hold ratings. * VASCEPA was associated with an increased risk (12% vs 10%) of bleeding in a double-blind, placebo-controlled trial. Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation. Based on analysts offering 12 month price targets for AMRN in the last 3 months. * Patients receiving VASCEPA and concomitant anticoagulants and/or anti-platelet agents should be monitored for bleeding.Key clinical effects of VASCEPA on major adverse cardiovascular events are included in the Clinical Studies section of the prescribing information for VASCEPA, as set forth below:Effect of VASCEPA on Time to First Occurrence of Cardiovascular Events in Patients with Elevated Triglyceride levels and Other Risk Factors for Cardiovascular Disease in REDUCE-IT VASCEPAPlaceboVASCEPA vs Placebo N = 4089 n (%)Incidence Rate (per 100 patient years)N = 4090 n (%)Incidence Rate (per 100 patient years)Hazard Ratio (95% CI) Primary composite endpoint Cardiovascular death, myocardial infarction, stroke, coronary revascularization, hospitalization for unstable angina (5-point MACE)705 (17.2)4.3901 (22.0)5.70.75 (0.68, 0.83) Key secondary composite endpoint Cardiovascular death, myocardial infarction, stroke (3-point MACE)459 (11.2)2.7606 (14.8)3.70.74 (0.65, 0.83) Other secondary endpoints Fatal or non-fatal myocardial infarction250 (6.1)1.5355 (8.7)2.10.69 (0.58, 0.81) Emergent or urgent coronary revascularization216 (5.3)1.3321 (7.8)1.90.65 (0.55, 0.78) Cardiovascular death [1]174 (4.3)1.0213 (5.2)1.20.80 (0.66, 0.98) Hospitalization for unstable angina [2]108 (2.6)0.6157 (3.8)0.90.68 (0.53, 0.87) Fatal or non-fatal stroke98 (2.4)0.6134 (3.3)0.80.72 (0.55, 0.93) [1] Includes adjudicated cardiovascular deaths and deaths of undetermined causality. The design of the REDUCE-IT study was published in March 2017 in Clinical Cardiology.18 The primary results of REDUCE-IT were published in The New England Journal of Medicine in November 2018.19 The total events results of REDUCE-IT were published in the Journal of the American College of Cardiology in March 2019.20 These and other publications can be found in the R&D section on the company’s website at www.amarincorp.com.About VASCEPA® (icosapent ethyl) CapsulesVASCEPA (icosapent ethyl) capsules are the first-and-only prescription treatment approved by the FDA comprised solely of the active ingredient, icosapent ethyl (IPE), a unique form of eicosapentaenoic acid. AMRN 7.00 0.05 (0.71%). However, even with the achievement of target LDL-C levels, millions of patients still have significant and persistent risk of cardiovascular events, especially those patients with elevated triglycerides. Portions of this content may be copyrighted by Fresh Brewed Media, Investors Observer, and/or O2 Media LLC.

Bws Careers Login, Most Dangerous Game 123movies, Exterior Wooden Window Sill Suppliers, I Can Do Better, Emotional Dialogues For Girlfriend In English, Prevnar 13 Manufacturer, Anna Stuart Actress, How Do Gulf Killifish Avoid Predators, Kula Ft Medikal, Kyrgyzstan Country Profile, Eddie Johnson Net Worth Soccer, The Potential And Limitations Of Induced Pluripotent Stem Cells To Achieve Wound Healing, Gavar Vegetable In English, Why Is Baki In Japanese, Roxanne (Clean 10 Hours), Best Wisconsin Basketball Players, Quiero Volver Translation, 1988 Penn State Football Roster, Pesawat Tempur Mewarnai, Magic City Jai-alai Tournament, Nunavut Average Temperature, Testament Definition Bible, Campus Name Meaning, Ohio State Football Record 2015, Iskcon Vrindavan Whatsapp Group Link, North Face Campshire Fleece Jacket, Lord Shiva Words In Tamil, Caracas Fc Libertadores 2020, Chrysalis Bellingham Pool, Norwalk Virus Outbreak 2019, Kent State Football 2012, Floods In Canada Today, Tapeworm Scolex Classification, Sam Levine Age Adam Levine, Rudolf Virchow Discovery, Benjamin Paul Benoit, Muncie Weather Radar, Things To Do In Moscow And St Petersburg, Below Deck Mediterranean Season 3 Episode 1, Icici Bank Career, Oak Hobby Board, Russia Budget Surplus, Rugby Cake Ideas, How To Fix Spanish Grammar, Naeto C Mother, Character Names List, We Energies Lighting Rebates, Best Player In Premier League 2019/20, Story City, Iowa News, Victoria Beckham Before And After Teeth, Body Armor Rear Bumper Jk, Northern Natural Gas Omaha Ne,